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Heavy fog and an ice-slickened highway contributed to a massive pre-Christmas 69-vehicle pileup in eastern Virginia on Sunday that left more than 50 people injured, two in critical condition, authorities said.

The chain-reaction crash happened just before 8 a.m. in the westbound lanes of Interstate 64 near Williamsburg, Virginia, Virginia State Police Sgt. Michelle Anaya said during a news conference Sunday afternoon.

“We do not know the cause of the initial accident, but we do know that fog and the icy road conditions were causative factors in this multi-vehicle crash,” Anaya said.

She said that shortly after the pileup occurred on westbound I-64, another eight-vehicle crash happened in the eastbound lanes, prompting state police to close the entire freeway for three hours. The westbound lanes of the interstates were not reopened until around 4:30 p.m, reports ABC News.

Photographs and aerial footage from the scene showed a long line of crumpled vehicles, some on top of each other, near the Queens Creek Bridge, northeast of downtown Williamsburg.

Anaya said 51 people were treated at the scene or taken by ambulance to one of four area hospitals.

York County, Virginia, Fire Chief Stephen Kopczynski said two people suffered critical injuries, but were expected to survive. He said another 11 victims were being treated for serious injuries.

“It could have been far worse and luckily there are no confirmed fatalities,” Anaya said.

Anaya said the crash occurred near a construction zone.

Ivan Levy told the Associated Press that he and his wife, Alena Levy, were in separate cars driving to Williamsburg when the massive wreck occurred.

Ivan Levy said he had slowed down and turned his hazard lights on when he found himself in thick fog.

“Next thing I know I see cars just start piling up on top of each other,” Ivan Levy said.

He said he was able to stop and avoid getting involved in the crash, but his wife was not as fortunate.

“It was just so scary,” Alena Levy told the AP as she was being treated for minor injuries at a hospital.

Ivan Levy said the car his wife crashed was a Christmas gift.

“She was all upset about the vehicle, and I was like, ‘Look, honey, it’s just metal,’” he said.

Anaya said 27 state troopers were on scene investigating the pileup and said it could take several days to determine the initial cause.

With millions of people expected to travel this week for the Christmas holiday, Anaya said the crash is a wake-up call to drivers.

“We always ask people to give yourselves plenty of time when you’re traveling, always wear your seatbelt, always pay attention, do not drive distracted as well,” Anaya said.