Mikel Arteta has named an unchanged side from the team that lost 2-1 to Everton.
Emile Smith Rowe has failed a late fitness test and misses out.
Alex Lacazette leads the line and captains the side.
Kieran Tierney starts, Thomas Partey lines up in midfield.
For injury-hit Southampton, 40-year-old Willy Caballero starts in goal after joining the Saints on a free transfer this week following injuries to Alex McCarthy and Fraser Forster.
Former Arsenal winger Theo Walcott is on the bench.
Arsenal confirmed XI: Ramsdale, Tomiyasu, White, Gabriel, Tierney, Partey, Xhaka, Saka, Odegaard, Martinelli, Lacazette.
Subs: Okonkwo, Smith Rowe, Maitland-Niles, Holding, Soares, Pepe, Tavares, Lokonga, Nketiah.
Southampton XI: Caballero, Livramento, Bednarek, Stephens, Walker-Peters, Redmond, Ward-Prowse, Diallo, Tella, Broja, Armstrong.
Subs: Lewis, Lyanco, Long, Perraud, Djenepo, Smallbone, Elyounoussi, Walcott, Valery.
Saturday 3.00pm GMT
Venue: Emirates Stadium
Referee: Jarred Gillett
