A groundbreaking study led by the University of Southern California Leonard Davis School of Gerontology reveals the transformative effects of a diet that mimics fasting, known as the fasting-mimicking diet (FMD), on human health. The research demonstrates significant reductions in signs of immune system aging, insulin resistance, and liver fat, resulting in a lower biological age for participants.
Developed by Professor Valter Longo’s laboratory at USC Leonard Davis School, the FMD entails a five-day regimen high in unsaturated fats and low in calories, protein, and carbohydrates. This diet aims to replicate the benefits of fasting while ensuring essential nutrient intake.
Professor Longo expressed, “This study shows for the first time evidence for biological age reduction from two different clinical trials, accompanied by evidence of rejuvenation of metabolic and immune function.”
Previous studies by Longo highlighted the myriad benefits of periodic FMD cycles, including stem cell regeneration, mitigating chemotherapy side effects, and alleviating signs of dementia in mice. In humans, FMD cycles have shown promise in reducing risk factors associated with diseases like cancer, diabetes, and heart disease.
Longo’s team observed that one or two monthly FMD cycles extended the lifespan and health span of mice. However, the effects of FMD on aging, biological age, liver fat, and immune system aging in humans remained unexplored.
The study assessed the impact of FMD on disease risks and cellular health in two groups of men and women aged 18 to 70. Participants underwent 3-4 FMD cycles per month, consuming the specialized diet for five days followed by their regular diet for 25 days. The FMD regimen included plant-based soups, energy bars, beverages, snacks, tea, and supplements.
Results indicated reduced diabetes risks, decreased abdominal and liver fat, and rejuvenated immune systems among FMD participants. Statistical analysis revealed an average biological age reduction of 2.5 years in the FMD group.
Lead authors Brandhorst and Levine emphasized the FMD’s potential as an accessible and effective method to enhance health without significant lifestyle changes. Longo underscores its role in disease prevention and improving healthspan.
The study underscores the promising benefits of the fasting-mimicking diet in mitigating disease risk factors and lowering biological age in humans. Its findings advocate for incorporating periodic FMD cycles as a proactive strategy for disease prevention and health enhancement.
